WFWW-Progesterone Options for IVF

WFWW-Progesterone Options for IVF


If you ask women who have gone through an IVF cycle which the part they consider as the most difficult, it would likely be the progesterone injections. Traditionally progesterone in oil has been used and consists of deep intramuscular injections of an oily substance. Since IVF became a clinical treatment thirty years ago, we have been searching for an effective, more acceptable alternative. As you may be aware Reproductive Partners in Los Angeles and Orange counties currently has an ongoing study comparing an FDA approved vaginal medication with a new subcutaneous, easier injection.
One of our sister Integramed practices has just reported in the journal Fertility & Sterility results of a study comparing intramuscular progesterone with a variety of vaginal preparations. Among patients using vaginal progesterone, there were no statistically significant differences in outcomes between the vaginal and IM progesterone treatment groups. There was a 50.0% pregnancy rate among patients treated with vaginal progesterone and a 51.5% rate among matched IM progesterone patients. The live birth rates were 47% in the IM versus 47.5% in the vaginal progesterone groups. There were no statistically significant differences in miscarriage rates between groups.
Our current study goes one step further by comparing the only vaginal progesterone approved by the FDA for pregnancy support, Endometrin, with a new easy subcutaneous injection. If you meet the inclusion criteria you can still join the study and be eligible for free progesterone medication and an honorarium. For more information, call your nearest Reproductive Partners office or (877) 273-7763.